ea0086mte7 | Reproductive and Neuroendocrinology | SFEBES2022
Migale Roberta
Unlike most organs whose fate is pre-determined, mammalian gonads are unique as they originate from a pair of bipotential genital ridges that can develop as either ovaries or testes depending on which genetic program is activated during embryonic life. The discovery of genes important for sex determination, notably SRY/SOX9 in the testis and FOXL2/WNT4 in the ovary, has benefited from the study of human disorders of sex development (DSD) and animal models, such as the mouse. H...